Spider-Man: Friend or Foe is a Spider-Man video game based on the comic book series and Spider-Man movies.

According to the company report, Spider-Man: Friend or Foe is a unique take on the media franchise. Inspired by the movies Spider-Man, Spider-Man 2, and Spider-Man 3, this action/adventure beat 'em up game reinterprets big-screen moments and battles with a humorous twist. Players team up with famous heroes from the Marvel Comics universe to combat villains and then convert them to sidekicks after defeating them in epic boss battles. The game includes a co-op multiplayer mode, as Spider-Man or a sidekick, in locations around the globe, including Tokyo, Egypt, and Nepal.

Spider-Man: Friend or Foe, along with most other games published by Activision that had used the Marvel licence, was de-listed and removed from all digital storefronts on January 1, 2014.