Twenty years after Pac-Man's first adventure in Pac-Land, Pac-Man returns one day to his house only to find it deserted. Toc-Man and his ghosts have kidnapped Pac-Man's friends, Ms. Pac-Man, Pac Jr., Baby Pac, Professor Pac, Pooka, and Chomp-Chomp the dog! Pac-Man must venture to Toc-Man's lair on Ghost Island to rescue his friends!

This version is a remake developed for the Game Boy Advance.